About
21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking
1528 Locust St
St. Louis,
MO
63103
TripAdvisor Rating:
195 Reviews | Write a ReviewThe Good, the Bad and the Ugly.
Reviewed By Mike B May 2026Stayed here due to a graduation. It was an edict property from Chase travel. Overall the property was nice but except for the museum on the second floor, it has a tired look that needs to be...
Full ReviewHas potential but definitely uneven experience
Reviewed By citimomma May 2026Very well designed rooms and super interesting lobby. Definitely a fun and unexpected location. However the high-end products in the hotel room in the bathroom are always empty and the dispensers do...
Full ReviewRoom for improvement
Reviewed By TravelerGuy802 May 2026I had business in St Louis so stayed here for a few nights. St Louis could sure use the business as the city has lots of vacant buildings and signs of entrenched poverty. The room was small for the...
Full ReviewWhat's Nearby
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TripAdvisor Rating:
195 Reviews | Write a ReviewThe Good, the Bad and the Ugly.
Reviewed By Mike B May 2026Stayed here due to a graduation. It was an edict property from Chase travel. Overall the property was nice but except for the museum on the second floor, it has a tired look that needs to be...
Full ReviewHas potential but definitely uneven experience
Reviewed By citimomma May 2026Very well designed rooms and super interesting lobby. Definitely a fun and unexpected location. However the high-end products in the hotel room in the bathroom are always empty and the dispensers do...
Full ReviewRoom for improvement
Reviewed By TravelerGuy802 May 2026I had business in St Louis so stayed here for a few nights. St Louis could sure use the business as the city has lots of vacant buildings and signs of entrenched poverty. The room was small for the...
Full Review