Planning a weekend girls’ trip? St. Louis has hotels for every style, from chic boutiques to spacious suites, where spa experiences and rooftop dining are only the beginning.
Strike a pose at every picture-perfect corner – think dazzling artworks, surprising designs and glittering skylines – then take your night to the next level with buzzing bars, trendy restaurants and live music just steps from your stay.
Whether you’re lounging poolside by day or dancing the night away, St. Louis sets the scene for the best girls’ trip in the books.
21c Museum Hotel St. Louis
Flirt with the Unexpected
Teeming with contemporary art exhibitions, Spanish culinary traditions and holistic wellness experiences, 21c Museum Hotel St. Louis welcomes the curious, the defiant and the restless. Add its signature waddle of Cracking Art penguins, and you’ve got the place to see and be seen on a weekend girls’ trip to the Gateway City.
Strike a pose with one of the hotel’s brilliant site-specific installations, then settle in for robust tapas at Idol Wolf. Adorned with warm earth tones, beautiful tile, wood accents and graceful arches, the restaurant specializes in small plates such as pan con tomate, patatas bravas, croquetas de jamón, gambas al ajillo and albondigas made with pork and beef.
For nearby nightlife, sip and savor at Scout’s, enjoy exclusive indulgences at Blood & Sand and hit the dance floor at Tin Roof. In the morning, revive and refuel at Good Press inside the boutique hotel, or swing by Latte Lounge + HG Eatery, where coffee buckets deliver a dose of caffeine and a guaranteed Insta moment.
Angad Arts Hotel St. Louis
Slay with Artful Stays
Surrounded by sensory delights in the Grand Center Arts District, Angad Arts Hotel St. Louis combines a boutique hotel stay and an immersive art experience for a creative weekend with your crew. Choose rooms based on color – red, yellow, green or blue – and then wander the property discovering carefully curated artwork that sparks surprise and delight around every corner.
For one of the best St. Louis photo ops, head to Art Bar, where craft cocktails and seasonal fare come with a stunning backdrop. The sky-high lounge also hosts festive popups around select holidays, adding an extra layer of fun to an already Instagram-worthy escape.
A short stroll away, Hidden Gems delivers an equally glamorous vibe. Packed with personality, the disco dive bar boasts pretty pink booths, 300 disco balls and dainty cocktails with cheeky names such as Material Girl, Manchild and Shine, Bitch. Upping the ante on girls’ night, the events calendar offers an activity for everyone, from karaoke to trivia to drag bingo. For a different vibe, revel in smashburgers and live music at The Key or join a jam session at The Dark Room at The Grandel – both just steps from the hotel.
Element St. Louis Midtown
Sleepover in Stylish Suites
Patio grills, rooftop bars, indoor pools – Element St. Louis Midtown has the makings of a memorable weekend away. The best part? The Marriot-branded hotel features a one-of-a-kind suite, providing an exclusive escape for your entire entourage.
Stepping through private double doors, you’ll find four simple yet spacious king rooms – each with its own bathroom – and a comfortable common area with a full kitchen, dining table, flat-screen TV and plenty of throw pillows and blankets for all your lounging needs.
Across the street, City Foundry STL turns every outing into an adventure. Savor chef-driven dishes at the food hall, compete in tech-infused miniature golf at Puttshack or sip wine in style at City Winery while enjoying live music. Hungry for something a little more refined? Vicia showcases the best of Midwest flavor in a bright, airy dining room with a front-row view of the buzzing kitchen.
Insider advice: You don’t have to step out every night. Stock up on drinks and snacks at Fresh Thyme, then hunker down in your Studio Commons suite for the ultimate movie night.
Four Seasons Hotel St. Louis
Toast to Five-Star Indulgence
Luxury reaches new heights at the Four Seasons Hotel St. Louis, where contemporary guest rooms frame grandiose Arch views, setting the scene for slow mornings, sunset selfies and late-night chats. On the eighth floor, dinner becomes an event at Ramsay’s Kitchen, a delicious outpost from celebrity chef Gordon Ramsay. Indulgent offerings such as tuna tartare, beef Wellington and sticky toffee pudding are served in swanky surroundings that call for a chic ensemble and another round.
When it reopens in June 2026, the on-site spa will further the relaxation factor. Refreshed features include redesigned wet facilities, intentional lounge spaces, upgraded treatment rooms and suites for shared experiences. Guests can move through a hot-cold therapy cycle designed to boost circulation, reduce soreness, improve flexibility and support mental wellbeing, positioning the spa as a restorative, holistic sanctuary in the heart of downtown.
When it’s time to trade robes for heels, 360 St. Louis extends the evening’s buzz. Elevated in every way, the party-packed bar atop the Hilton St. Louis at the Ballpark fuels spirited conversations with shareable smalls and signature sips.
To take a bigger bite out of downtown flavor, snag a seat at Katie’s in Ballpark Village. The award-winning restaurant features modern interpretations of regional Italian cuisine – think cannellini bean dip, butternut squash tortelloni, wild boar tagliatelle and pancetta and fig pizza. On sunny days, stop by the takeout window for a personal pie and enjoy it al fresco in Together Credit Union Plaza. Brunch lovers are equally spoiled with oversized hazelnut sweet rolls, decadent lemon-ricotta pancakes, hen of the woods frittata and blood orange marmalade and prosciutto burrata, among other morning specials.
Feeling lucky? Steps from the Four Seasons, Horseshoe St. Louis pairs classic table games with whirring slot machines and sleek bars with midnight munchies. Here, the house might play its hand, but the best bet is always on yourself.
Hotel Saint Louis
Experience Vintage VIP Status
Designed by famed architect Louis Sullivan and refined by his protégé Frank Lloyd Wright, Hotel St. Louis stands at the crossroads of historic and hip. Within the bespoke environment, a rejuvenating spa and a rooftop pool spark remarkable experiences as unique as each guest.
Beyond the hotel, the city’s nightlife beckons. Broadway Oyster Bar serves freshly shucked oysters alongside gloriously funky beats in a New Orleans-style atmosphere. Regional and national acts play seven nights a week, filling the dance floor with a diverse crowd of exuberant patrons.
Over at Tin Roof, the energy is also electric. Catch everything from country hits to classic rock and hip-hop to house tracks as DJs and live performers keep the dance floor moving.
For a sparkling escape from reality, duck into The Boom Boom Room, the country’s largest burlesque club. Choreographed dances and aerial acrobatics, sequins and sex appeal create a vintage Las Vegas vibe where glamour and mischief mingle. If you’re up for it, there are also opportunities for audience participation!
Le Méridien St. Louis Clayton
Bask in Rooftop Revelry
A swimming pool, a curling rink, a movie theater – the roof at Le Méridien St. Louis Clayton is a hive of activity year-round. Depending on the season, your inner circle can bask in the sun or frolic in the snow while taking in sweeping views of downtown Clayton.
Beginning March 12, 2026, the hotel will welcome Le Petit Chef, an immersive dining experience transforming the hospitality industry. Pairing quality cuisine with cinematic storytelling, the multicourse meal transforms dinner into a fully choreographed event led by a master of ceremonies. Four menu options are available, whether you’re craving lobster thermidor, grilled ribeye or stuffed squash.
In Clayton, going hungry isn’t an option. Within walking distance of the hotel, the intersection of Hanley Road and Wydown Boulevard packs an impressive culinary lineup: contemporary Malaysian at Akar, French fare at Bistro La Floraison, steak and seafood at Wright’s Tavern, Iberian specialties at Bar Moro, Italian soul food at Peno and kosher noshes at Protzel’s Delicatessen.
Continue your food tour in the fabulously designed dining rooms of Casa Don Alfonso in The Ritz-Carlton, St. Louis and Louie in the DeMun neighborhood. For light bites and a glass (or bottle) of wine, pop into Sasha’s Wine Bar, conveniently located on the same street as Clementine’s Naughty and Nice Creamery when your sweet tooth calls. The ice cream shop’s playful flavors run the gamut, from Espresso Royale and Salted Caramel Cookies and Cream to Lemon Poppyseed and Gooey Butter Cake. Bring your appetite!
The Royal Sonesta Chase Park Plaza St. Louis
Kick It in Style
For more than a century, well-heeled wanderers have checked into The Royal Sonesta Chase Park Plaza St. Louis. Set along historic Route 66 in the Central West End, the grand hotel retains its mid-century charm, enhanced by modern-day allure. In summer, the Mediterranean-inspired pool becomes a social hub, where plush loungers, chilled cocktails and swaying palm trees create the ultimate girls-trip backdrop. When temperatures dip, slip inside for a cozy movie night at the Chase Park Plaza Cinema.
Step onto the street and you’re moments from some of the best St. Louis photo ops. In front of the World Chess Hall of Fame, the world’s largest chess piece stands 20 feet tall, while inside the breathtaking Cathedral Basilica of St. Louis, shimmering mosaics cover the ceiling and walls in dazzling detail.
Luckily, some of the most photogenic spots in the area are also delicious! Begin the day with garden-inspired brunch at Bowood by Niche, enjoy a leisurely lakeside lunch at The Boathouse at Forest Park and celebrate happy hour at Jujube Inn. For dinner, tropical flavors shine at Yellowbelly, followed by a sweet finale at Clementine’s Naughty & Nice Creamery. Just like that, your itinerary is set.
Seven Gables Inn
Unwind in Storybook Surroundings
Nestled in the fashionable Clayton business district, Seven Gables Inn strikes the perfect balance between European countryside comfort and up-to-date elegance. Offering a serene escape from daily life, the intimate inn also provides easy access to the neighborhood’s favorite cafés, cocktail bars and entertainment venues.
Brunch is a must at Ivy Cafe, Half & Half or Colleen’s Café – Jennifer Coolidge posted a rave review of the latter when she was in town giving a WashU commencement speech, so you know it’s worth a stop! If you’re craving Asian classics, try The Bao or Jinzen, and then raise a glass to friendship at Bemiston Cocktail Club.
For a bit more action, check out playful adventures in the heart of downtown Clayton. Take aim at Flight Club, which has revolutionized the traditional game of darts, or hit the greens at Five Iron Golf, where you can practice your swing in between baskets of bottomless wings.
Tuxedo Park STL
Make Yourself at Home
On a quaint street in a charming neighborhood, Tuxedo Park STL welcomes guests with open arms – and Labrador kisses for any dog-lovers in the group. Listed on the National Register of Historic Places, the luxury bed-and-breakfast in Webster Groves has just four rooms, making it an ideal spot for you and your gal pals to take over for the weekend.
“Most people don’t know what to expect when they book a room at this B&B in the middle of an urban area,” owner Maureen Elliott says, “and I love watching their faces when they come through the door because they’re usually blown away by the interior.”
One of the perks of this suburban setting is its proximity to world-class arts organizations and award-winning restaurants. Catch a performance by Opera Theatre of Saint Louis or The Repertory Theatre of St. Louis, or settle in for live music, cold brews and tavern vibes at Frisco Barroom.
After more than a decade, Olive + Oak still boasts one of the hottest tables in town, while Madrina is the stylish new kid on the block. Both pride themselves on warm hospitality, chic décor, brilliant bites and innovative sips. If cocktails are calling your name, belly up to the bar at Off Elm, where drinks have personalities of their own, with names like Be My Bay, Spicy Johnny and Gorbals Vampire.
And if you don’t get your fill of coffee, quiche and conversation around the B&B’s breakfast bar, swing by 23 West Coffee, Telva at the Ridge, The Annex and The Clover & the Bee – all adorable pit stops while you’re out exploring.
